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Brand name: amoxicillin
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Hypersensitivity reactions to amoxicillin are more likely in patients with a history of allergy, asthma, hay fever, or urticaria. Urticarial rash, erythematous maculopapular rash, edema, hypotension, fever, eosinophilia, and dyspnea have been associated with hypersensitivity reactions to amoxicillin. The action of clavulanic acid extends the antimicrobial spectrum of amoxicillin to include bacteria resistant to amoxicillin and other β-lactam antibiotics. Erythematous maculopapular rashes occur frequently in patients with infectious mononucleosis who take amoxicillin; these may be due to hypersensitivity. Rare cases of psychosis associated with amoxicillin therapy have been reported but may have been due to underlying infection or concomitant medication. Three out of four patients with infectious mononucleosis and an amoxicillin-associated rash displayed hypersensitivity to amoxicillin and ampicillin by skin tests and lymphocyte transformation tests. Amoxicillin rashes occur more frequently in patients with unrecognized infectious mononucleosis. Am J Clin Path 45:493, 1966) utilized 30 mcg Augmentin™ discs for estimating the susceptibility of bacteria to amoxicillin/clavulanic acid tablets. This rash is not necessarily indicative of a lifelong amoxicillin hypersensitivity. In addition, C difficile pseudomembranous colitis should be considered in patients who develop severe or prolonged diarrhea during or following amoxicillin-clavulanate therapy. Whenever such reactions occur, amoxicillin should be discontinued unless, in the opinion of the physician, the condition being treated is life-threatening and amenable only to amoxicillin therapy.
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